Rolf E Brenner Selected Research

Proteoglycans (Proteoglycan)

11/2015	Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo.
11/2012	Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches.
8/2012	Development of a new biomechanically defined single impact rabbit cartilage trauma model for in vivo-studies.
8/2011	Single impact trauma in human early-stage osteoarthritic cartilage: implication of prostaglandin D2 but no additive effect of IL-1β on cell survival.

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Rolf E Brenner Research Topics

Disease

14	Wounds and Injuries (Trauma) 01/2022 - 08/2011
6	Osteoarthritis 01/2023 - 11/2004
6	Inflammation (Inflammations) 02/2020 - 05/2009
2	Intervertebral Disc Degeneration 01/2023 - 01/2021
2	Pain (Aches) 01/2023 - 01/2020
2	Osteophyte 01/2023 - 11/2015
2	Knee Osteoarthritis 01/2020 - 01/2020
1	Postoperative Pain 01/2023
1	Insulin Resistance 11/2022
1	Hypothermia 01/2018
1	Athletic Injuries (Sports Injuries) 01/2018
1	Hemarthrosis 11/2015
1	Multiple Trauma (Multiple Injuries) 01/2015
1	Bone Fractures (Bone Fracture) 01/2015
1	Necrosis 08/2012
1	Infections 09/2011
1	Joint Diseases (Joint Disease) 05/2009
1	Perinatal Death 04/2007
1	Respiratory Insufficiency (Respiratory Failure) 04/2007
1	Osteoporosis 04/2004
1	Bone Resorption 01/2002

Drug/Important Bio-Agent (IBA)

6	EnzymesIBA 01/2023 - 08/2012
4	Dinoprostone (PGE2)FDA Link 01/2023 - 01/2015
4	Interleukin-6 (Interleukin 6)IBA 01/2018 - 08/2011
4	Proteoglycans (Proteoglycan)IBA 11/2015 - 08/2011
3	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2023 - 11/2015
3	Collagen Type II (Type II Collagen)IBA 06/2019 - 01/2018
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 01/2002
3	CytokinesIBA 01/2013 - 05/2009
2	Acetylcysteine (Siran)FDA LinkGeneric 06/2019 - 01/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 11/2012
2	Matrix Metalloproteinases (MMPs)IBA 01/2018 - 11/2015
2	Complement System Proteins (Complement)IBA 01/2015 - 09/2011
2	ProstaglandinsIBA 11/2012 - 08/2011
1	AdipokinesIBA 11/2022
1	Simvastatin (Zocor)FDA LinkGeneric 01/2022
1	Fluvastatin FDA Link 01/2022
1	HexosaminesIBA 07/2021
1	N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime (PUGNAC)IBA 07/2021
1	Glucosamine (Dona)IBA 07/2021
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Cartilage Oligomeric Matrix ProteinIBA 01/2020
1	Bone Morphogenetic Protein 7IBA 06/2019
1	AntioxidantsIBA 01/2019
1	HMGB1 Protein (HMG1)IBA 01/2019
1	CaspasesIBA 01/2019
1	Cycloheximide (Cicloheximide)IBA 01/2019
1	ThrombospondinsIBA 01/2018
1	Cysteine (L-Cysteine)FDA Link 01/2018
1	DisintegrinsIBA 01/2018
1	Metalloproteases (Metalloproteinases)IBA 01/2018
1	Proteins (Proteins, Gene)FDA Link 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2018
1	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2015
1	InterleukinsIBA 11/2015
1	Interleukin-8 (Interleukin 8)IBA 01/2015
1	ChemokinesIBA 01/2015
1	RNA (Ribonucleic Acid)IBA 01/2015
1	AnaphylatoxinsIBA 01/2015
1	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/2013
1	Prostaglandin D2IBA 08/2011
1	Phosphotransferases (Kinase)IBA 08/2011
1	SB 203580IBA 05/2009
1	AgrinIBA 04/2007
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 11/2004
1	progelatinaseIBA 11/2004
1	Heparin (Liquaemin)FDA LinkGeneric 04/2004

Therapy/Procedure

2	Arthroplasty 01/2023 - 01/2020
2	Therapeutics 01/2018 - 11/2012
1	Replacement Arthroplasty 01/2023
1	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2020
1	Cryotherapy (Therapy, Cold) 01/2018
1	Orthopedic Procedures 09/2011